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Deer vaccine may prevent brain disorder in humans

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New York: A vaccine that researchers developed to fight a fatal brain disorder in animals also holds promise for similar brain infections among humans.
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The study marks a scientific milestone as it is the successful vaccination of deer against chronic wasting disease (CWD), a fatal brain disorder caused by unusual infectious proteins known as prions that propagate by converting otherwise healthy proteins into a disease state.

According to researchers, this vaccine may also work against human brain diseases suspected to be caused by prion infections, such as Creutzfeldt-Jakob disease, kuru, familial insomnia, and even Alzheimer’s disease.

“Now that we have found that preventing prion infection is possible in animals, it is likely feasible in humans as well,” said senior study investigator and neurologist Thomas Wisniewski, a professor at New York University Langone Medical Center .

For the study, five deer were given the vaccine and another six were given a placebo.

The animals receiving the vaccine were given eight boosters over 11 months until key immune antibodies were detectable in blood, saliva, and faeces.

Within two years, all of the deer who were given the placebo developed chronic wasting disease. Four deer, who were given the real vaccine, took significantly longer to develop infection and the fifth one continues to remain infection free.

The researchers made the vaccine using Salmonella bacteria, which easily enters the gut, to mirror the most common mode of natural infection — ingestion of prion-contaminated food or faeces.

To prepare the vaccine, the team inserted a prion-like protein into the genome of an attenuated, or no longer dangerous, Salmonella bacterium. This engineered the Salmonella to induce an immune response in the gut, producing anti-prion antibodies.

The study appeared online in the journal Vaccine.

Corona

Covid toll in Karnataka is a worrying sign for state government

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Even though Karnataka recorded the lowest number of Covid deaths in April since the virus struck first in 2020, the state is recording a rise in the positivity rate (1.50 per cent). Five people died from the Covid infections in April as per the statistics released by the state health department. In March, the positivity rate stood around 0.53 per cent. In the first week of April it came down to 0.38 per cent, second week registered 0.56 per cent, third week it rose to 0.79 per cent and by end of April the Covid positivity rate touched 1.19 per cent.

on an average 500 persons used to succumb everyday in the peak of Covid infection, as per the data. Health experts said that the mutated Coronavirus is losing its fierce characteristics as vaccination, better treatment facilities and awareness among the people have contributed to the lesser number of Covid deaths.

During the 4th and 6th of April two deaths were reported in Bengaluru, one in Gadag district on April 8, two deaths were reported from Belagavi and Vijayapura on April 30. The first Covid case was reported in the state in March 2020 and three Covid deaths were recorded in the month. In the following month 21 people became victims to the deadly virus, and May 2020 recorded 22 deaths. The death toll recorded everyday after May crossed three digits. However, the third wave, which started in January 2

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