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Lose weight while burning more muscle energy

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Washington: Researchers have developed a targeted approach to override the “energy saving” mode and allow muscle to burn more energy, even during low to moderate exercise.

The new findings may provide the basis of a therapy that could help people to overcome the body’s natural resistance to weight loss.

“This study shows for the first time that this energy efficiency can be manipulated in a clinically translatable way,” said Denice Hodgson-Zingman from the University of Iowa and co-author of the study.

“While such an approach would not replace the need for a healthy diet or exercise, it could jump start the process of weight loss by overcoming the initial hurdles imposed by our energy-efficient physiology,” Denice noted.

An earlier study found that a protein called ATP-sensitive potassium (KATP) channel is a powerful modulator of energy efficiency in skeletal muscle even during low-intensity activity.

Now, the team has shown that altering the activity of the KATP protein causes skeletal muscles to become less efficient and burn more calories.

For the study, the team made a compound called a vivo-morpholino, which suppresses production of KATP.

Injecting this compound into the thigh muscles of mice produced a local loss of the protein but did not affect the protein in other organs or even in neighbouring skeletal muscles.

The injected muscles burned more calories than untreated muscle without significantly affecting the muscle’s ability to tolerate exercise.

“By making skeletal muscles less energy efficient, they burn more calories, even while doing normal daily activities,” said Leonid Zingman from the University of Iowa and co-author.

“With this intervention, the benefits of exercise in burning calories could be accessible to a broader range of people by making the calorie burning effects of skeletal muscle greater even at low levels of activity that most people would be able to undertake,” Zingman said.

The study appeared in the journal Molecular Therapy.

Corona

Covid toll in Karnataka is a worrying sign for state government

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Even though Karnataka recorded the lowest number of Covid deaths in April since the virus struck first in 2020, the state is recording a rise in the positivity rate (1.50 per cent). Five people died from the Covid infections in April as per the statistics released by the state health department. In March, the positivity rate stood around 0.53 per cent. In the first week of April it came down to 0.38 per cent, second week registered 0.56 per cent, third week it rose to 0.79 per cent and by end of April the Covid positivity rate touched 1.19 per cent.

on an average 500 persons used to succumb everyday in the peak of Covid infection, as per the data. Health experts said that the mutated Coronavirus is losing its fierce characteristics as vaccination, better treatment facilities and awareness among the people have contributed to the lesser number of Covid deaths.

During the 4th and 6th of April two deaths were reported in Bengaluru, one in Gadag district on April 8, two deaths were reported from Belagavi and Vijayapura on April 30. The first Covid case was reported in the state in March 2020 and three Covid deaths were recorded in the month. In the following month 21 people became victims to the deadly virus, and May 2020 recorded 22 deaths. The death toll recorded everyday after May crossed three digits. However, the third wave, which started in January 2

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