World
Asian herb holds promise against Ebola
Washington: A promising small molecule derived from an Asian herb has successfully inhibited infection of human white blood cells, thus preventing Ebola virus disease in mice, US researchers report.
Robert Davey, a scientist at the Texas biomedical research institute and his team found that Tetrandrine showed to be a potent small molecule inhibiting infection of human white blood cells in lab experiments.
Tetrandrine is isolated from the root of Stephania tetrandra S. Moore, a Chinese medicinal herb which has been used traditionally as a remedy for neuralgia and arthritis.
Ebola virus begins its entry into a cell by first binding to several types of cell surface proteins.
Then the virus is taken into the cell and follows an endosomal route or membrane-bound route that transports the virus to various cell compartments.
From previous studies, Davey said that during this endosomal process, he knew that calcium signalling in cells, which allow cells to transmit electrical charges to one another, controls many of the processes in the cell and was important for Ebola virus infection.
“We were not able, however, to pinpoint the mechanisms involved in this process,” Davey said.
In new research, the team discovered that two pore channels (TPCs) are the key calcium sensor involved in Ebola virus infection.
In addition to identifying this critical mechanism to infection, Davey’s team also showed that drugs targeting this interaction show some efficacy as potential treatments against Ebola virus disease.
They found Tetrandrine protected mice from disease without obvious side effects and was the best candidate for further animal testing.
“It was the most potent compound tested, gave little evidence of cytotoxicity and required a smaller dose to be effective and tolerated,” the authors wrote.
“When we tested in mice, the drugs stopped virus replication and saved most of them from disease,” Davey pointed out.
Essentially, this drug shows an ability to stop the virus before it has a chance to interact with cellular factors, thus stopping the virus from continuing its infection process.
The next step is to test both the safety and effectiveness of the interaction of the drug with Ebola virus in non-human primates.
According to the World Health Organisation (WHO), the latest outbreak of Ebola virus disease has caused the death of more than 9,400 people worldwide.
The research was detailed in the journal Science.
Lucknow: Vishal Singh, a renowned social worker from Lucknow, also known as Foodman, has once again made India proud. He was honored by the Happy Hands Gloves Cooperative Limited Company in Korathai, Thailand, for his work with the Hunger Free World Mission.
The Hunger Free World Mission’s meeting was held in Korathai, Thailand, under Vishal Singh’s leadership. Representatives from several countries, including Mr. Raja Dwivedi (Managing Director of Happy Hands Gloves Limited), Thailand Coordinator Mr. Raja Mishra, and member Mr. Varun Singh, attended the event.
Under Vishal Singh’s leadership, the attendees took a pledge to work together toward creating a hunger-free world.
Speaking on the occasion, Vishal Singh explained that the main goal of the Hunger Free World Mission is social participation. He said the mission is not just about feeding people but also about meeting other basic needs of those who are struggling. The mission focuses on helping families of terminally ill patients in hospitals by providing food and shelter. It also works to fulfill essential needs like education, jobs, and care for the elderly.
For the last 16 years, the Vijay Sri Foundation has been providing free services, benefiting thousands of people. Vishal Singh highlighted that the mission aims to gain global recognition like other organizations such as WHO, WWF, and Red Cross, which work for social causes.
During this meeting, Vishal Singh was appointed as the Chairman of the Hunger Free World Mission by representatives from various countries. They also discussed holding regular meetings in different countries to push the mission forward.
Business tycoon Dr. Abhishek Verma has also supported this humanitarian mission, vowing to promote the idea of “Seva Parmo Dharma” (Service is the highest duty) worldwide. Vishal Singh praised him, stating that people like Dr .Abhishek Verma inspire others to work for the betterment of society.
Recently, Romania’s Ambassador, Mr . Daniela Sezonov Ţane, invited Vishal Singh to the Romanian Embassy in Delhi, where they discussed the mission in detail. Impressed by his humanitarian work, she honored Vishal Singh and invited him to Romania to take the mission forward .
Food man Vishal Singh has been serving the people of India for the past 16 years. Through the Vijay Sri Foundation, he provides free meals to cancer patients & their families ,shelter, and education for women & children along with running free old-age homes in Lucknow.
In addition to his humanitarian work, Vishal Singh also addresses issues like crime and corruption through his role as Chairman of Seva Path Media and Managing Director of Vijay Sri Foundation.
During the COVID-19 pandemic, Vishal Singh and his team worked tirelessly to provide food and help to the needy, including starving children, elderly citizens, and pregnant women. Despite contracting the virus himself, he continued to assist others after his recovery. He even created a life-saving oxygen regulator using household items, which was praised by doctors both in India and abroad.
In his address at the meeting, Vishal Singh spoke about his mission to create a hunger-free world. He pointed out that India’s large population, along with issues like unemployment and poverty, has caused the country to fall on the Hunger Index. He urged people to contribute just one handful of grains daily to help create a hunger-free world.
He concluded by saying that through social participation, we can empower the people around us, meet their basic needs, and work together to build a stronger, more prosperous, and developed society.
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