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Drug target for Ebola-like viruses identified

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Ottawa: Researchers have identified the Achilles’ heel of haemorrhagic fever viruses, targeting which can help combat the diseases that they cause.

Viral hemorrhagic fevers (VHFs) refer to a group of illnesses caused by several distinct families of viruses, including the Ebola virus.

These diseases present a dramatic risk to human health as they often spread quickly and kill a high percentage of infected individuals, as demonstrated by the recent Ebola outbreaks.

“Although our work does not directly lead to treatments on a short term, it does identify a process where the virus could be vulnerable to drug therapy, or how we might design an attenuated viral strain for vaccine development,” said first author Normand Cyr from the University of Montreal in Canada.

The researchers found that certain viral proteins essential for propagation of the virus imitate human DNA repair factors and using drugs to dam this chemical reaction would condemn the disease’s infectiousness.

“Identification of the Achilles heels of haemorrhagic fever viruses like the Rift Valley fever virus will help inspire additional research and eventually lead to the development of new therapeutic strategies to treat these deadly tropical infections,” Cyr noted.

The researchers used Nuclear Magnetic Resonance (NMR) spectroscopy studies to investigate the structural properties of an important viral protein required for virulence of the Rift Valley fever virus, a virus that causes infections in both humans and livestock similar to the Ebola virus.

“The structural details reported show that the viral protein uses a simple motif that is similar to that found in human DNA repair proteins, and blocking this binding event with drugs would certainly weaken the virulence of the virus,” senior study co-author James Omichinski, professor at the University of Montreal explained.

The study appeared in the journal Proceedings of the National Academy of Sciences of the US (PNAS).

Corona

Covid toll in Karnataka is a worrying sign for state government

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Even though Karnataka recorded the lowest number of Covid deaths in April since the virus struck first in 2020, the state is recording a rise in the positivity rate (1.50 per cent). Five people died from the Covid infections in April as per the statistics released by the state health department. In March, the positivity rate stood around 0.53 per cent. In the first week of April it came down to 0.38 per cent, second week registered 0.56 per cent, third week it rose to 0.79 per cent and by end of April the Covid positivity rate touched 1.19 per cent.

on an average 500 persons used to succumb everyday in the peak of Covid infection, as per the data. Health experts said that the mutated Coronavirus is losing its fierce characteristics as vaccination, better treatment facilities and awareness among the people have contributed to the lesser number of Covid deaths.

During the 4th and 6th of April two deaths were reported in Bengaluru, one in Gadag district on April 8, two deaths were reported from Belagavi and Vijayapura on April 30. The first Covid case was reported in the state in March 2020 and three Covid deaths were recorded in the month. In the following month 21 people became victims to the deadly virus, and May 2020 recorded 22 deaths. The death toll recorded everyday after May crossed three digits. However, the third wave, which started in January 2

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