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New method to develop more efficient drugs

Published

9 years ago

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London: Scientists have developed a new approach to develop highly-potent drugs which could overcome current shortcomings of low drug efficacy and multi-drug resistance in patients.

The study that appeared in Nanomedicine identified a new mechanism of targeting multi-subunit complexes that are critical to the function of viruses, bacteria or cancer.

Thus the mechanism will reduce or possibly even eliminating their resistance to targeted drugs.

“Efficacy is the key in drug development,” said Peixuan Guo, director of Britain’s Nanobiotechnology Centre and one of the top nanobiotechnology experts in the world.

“Inhibiting multisubunit targets works similar to the series-circuit Christmas decorating light chains; one broken bulb turns off the entire lighting system,” Guo noted.

By targeting RNA, this method allows for killing or disabling the RNA or protein without requiring the inhibition of multiple pathways that might be used by the organism to remain active and viable.

Using this method, a single subunit targeting to the target RNA or protein subunits that is unique and assenting for the organism, the organism will be disabled or die and thus, no longer able to cause disease.

“One of the vexing problems in the development of drugs is drug resistance,” said Tim Tracy, former Dean of the UK College of Pharmacy and current UK provost.

“Guo’s study has identified a new mechanism of efficiently inhibiting biological processes that are critical to the function of the disease-causing organism, such that resistance is minimized or eliminated,” Tracy said.

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Business

Apple is giving a huge discount on its gadgets: Details inside

Published

3 years ago

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May 5, 2022

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If you want to buy an iPhone and were waiting for a nice offer, then we have a piece of good news for you! Amazon Summer Sale May 2022 has begun and they are offering major discounts on various smartphones, laptops, and smart TVs, among others.

The sale is live now on the e-commerce platform with no-cost EMI options and exchange discounts on various products. In addition to this, Amazon has also partnered with several banks including ICICI, Kotak Bank, and RBL so that customers get instant discounts of up to 10% using their cards and EMI transactions.

Customers can easily enjoy this summer sale and get massive discounts on iPhones. They can also compare prices on Flipkart Big Saving Days Sale 2022 before making a purchase.

 

Amazon Summer Sale May 2022: Discount offer on iPhone 13 

Apple’s coveted phone model iPhone 13 in the 128 GB storage model will be available during the Amazon Summer Sale May 2022 for Rs 64,900. The MRP of the phone is Rs 79,900. This means that the customers will be able to enjoy a discount of up to Rs 15,000 on the purchase of the iPhone 13.

If you have an old iPhone in working condition then you will also be eligible to receive another additional discount worth up to Rs 17,000 on the iPhone 13.

Buy at Rs. 64,900 (MRP – Rs. 79,900)

Features of Apple iPhone 13 

The iPhone is powered by an A15 Bionic processor with 6 core CPU. Apart from this, it has 16 core neural engines. With the iPhone 13, up to 512 GB of storage will be available. The iPhone 13 has a 6.1-inch Retina XDR display with 1000 nits brightness.

The iPhone 13 has a 12-megapixel dual rear camera setup. This time a new wide-angle camera has been given, whose aperture is f/1.6. With this, there is support for sensor optical stabilisation. Night mode has been made better than before. The second lens is also 12 megapixels ultra-wide and has an aperture of f/2.4.

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