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Gene responsible for metabolic syndrome discovered

Published

10 years ago

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New York:  The absence of a gene called TLR5 on the intestinal surface leads to alterations in gut bacteria and promotes inflammation, leading to metabolic syndrome, says a study.

Metabolic syndrome is a combination of risk factors that increases a person’s risk for heart disease, diabetes and stroke.

“They (the results) confirm the concept that altered microbiota can promote low-grade inflammation and metabolic syndrome and advance the underlying mechanism,” said Andrew Gewiindexrtz, professor at Georgia State University.

“We have filled in a lot of the details about how it works,” Gewirtz added.

“It is the loss of TLR5 on the epithelium, the cells that line the surface of the intestine and their ability to quickly respond to bacteria. That ability goes away and results in a more aggressive bacterial population that gets closer in and produces substances that drive inflammation,” Gewirtz explained.

Normally, the bacteria are in the mucous layer at a certain distance away from epithelial cells.

The researchers showed that altered gut microbiota is more aggressive in infiltrating the host and gets very close to the epithelium.

This altered population produces substances, namely flagellin and lipopolysaccharide that further promote inflammation, the findings showed.

For the study, the research team compared mice that were siblings and littermates, making all conditions in the study the same.

The mice only differed by whether they were missing a specific gene, TLR5.

“These results suggest that developing a means to promote a more healthy microbiota can treat or prevent metabolic disease,” Gewirtz pointed out.

The findings were published in the journal Gastroenterology.

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Apple is giving a huge discount on its gadgets: Details inside

Published

3 years ago

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May 5, 2022

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If you want to buy an iPhone and were waiting for a nice offer, then we have a piece of good news for you! Amazon Summer Sale May 2022 has begun and they are offering major discounts on various smartphones, laptops, and smart TVs, among others.

The sale is live now on the e-commerce platform with no-cost EMI options and exchange discounts on various products. In addition to this, Amazon has also partnered with several banks including ICICI, Kotak Bank, and RBL so that customers get instant discounts of up to 10% using their cards and EMI transactions.

Customers can easily enjoy this summer sale and get massive discounts on iPhones. They can also compare prices on Flipkart Big Saving Days Sale 2022 before making a purchase.

 

Amazon Summer Sale May 2022: Discount offer on iPhone 13 

Apple’s coveted phone model iPhone 13 in the 128 GB storage model will be available during the Amazon Summer Sale May 2022 for Rs 64,900. The MRP of the phone is Rs 79,900. This means that the customers will be able to enjoy a discount of up to Rs 15,000 on the purchase of the iPhone 13.

If you have an old iPhone in working condition then you will also be eligible to receive another additional discount worth up to Rs 17,000 on the iPhone 13.

Buy at Rs. 64,900 (MRP – Rs. 79,900)

Features of Apple iPhone 13 

The iPhone is powered by an A15 Bionic processor with 6 core CPU. Apart from this, it has 16 core neural engines. With the iPhone 13, up to 512 GB of storage will be available. The iPhone 13 has a 6.1-inch Retina XDR display with 1000 nits brightness.

The iPhone 13 has a 12-megapixel dual rear camera setup. This time a new wide-angle camera has been given, whose aperture is f/1.6. With this, there is support for sensor optical stabilisation. Night mode has been made better than before. The second lens is also 12 megapixels ultra-wide and has an aperture of f/2.4.

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