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Researchers develop new treatment for colorectal cancer

Published

9 years ago

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Singapore: A new research lately revealed by National University of Singapore (NUS) has found that a molecule drug combining with chemotherapy might treat colorectal cancer.

The researchers demonstrated the efficiency of the drug called “PRIMA-1met” in inhibiting the growth of colorectal cancer cells.

Colorectal cancer is the cancer of the large intestine (colon and rectum) and it is known for its poor long term survival rates among adults.

“We are optimistic that the development of this drug as a targeted therapeutic approach against colorectal cancer, together with chemotherapy, holds good potential for patients,” said lead researcher Chng Wee Joo, professor at National University of Singapore (NUS).

In this study, the team found PRIMA-1met to be most effective in killing colorectal cancer cells that contain the mutated p53, a tumour suppressor gene that promotes death of cancer cells.

Unlike most anti-cancer drugs which works by inducing damage to DNA and often has serious side effects, PRIMA-1met is more favourable as it restores the structure and function of the mutated gene and specifically promotes the death of cancer cells, the researchers said.

Moving forward, the researchers plan to test if the combination of this drug, with anticancer drugs such as Fluorouracil and Oxaliplatin, which are commonly used for the treatment of colorectal cancer, will optimise the results of chemotherapy.

The study was published online in the journal Oncotarget.

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Corona

Covid toll in Karnataka is a worrying sign for state government

Published

3 years ago

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May 4, 2022

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Even though Karnataka recorded the lowest number of Covid deaths in April since the virus struck first in 2020, the state is recording a rise in the positivity rate (1.50 per cent). Five people died from the Covid infections in April as per the statistics released by the state health department. In March, the positivity rate stood around 0.53 per cent. In the first week of April it came down to 0.38 per cent, second week registered 0.56 per cent, third week it rose to 0.79 per cent and by end of April the Covid positivity rate touched 1.19 per cent.

on an average 500 persons used to succumb everyday in the peak of Covid infection, as per the data. Health experts said that the mutated Coronavirus is losing its fierce characteristics as vaccination, better treatment facilities and awareness among the people have contributed to the lesser number of Covid deaths.

During the 4th and 6th of April two deaths were reported in Bengaluru, one in Gadag district on April 8, two deaths were reported from Belagavi and Vijayapura on April 30. The first Covid case was reported in the state in March 2020 and three Covid deaths were recorded in the month. In the following month 21 people became victims to the deadly virus, and May 2020 recorded 22 deaths. The death toll recorded everyday after May crossed three digits. However, the third wave, which started in January 2

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