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Novel protein acts as research tool for Alzheimer’s disease

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Alzheimer's diseaseNew York : Scientists have designed a new protein that may act as an essential laboratory tool to help understand why nerve cells die in people diagnosed with Alzheimer’s.

The new protein which closely resembles the Amyloid-beta — proteins involved in Alzheimer’s disease — in size and shape, but contains two different amino acids, the building blocks that proteins are made up of.

These changes mean that the new protein does not form amyloid fibres or sticky clumps, and, unlike Amyloid-beta, is not toxic to nerve cells.

“Our study clearly shows that the aggregation of Amyloid-beta into bigger species is critical in its ability to kill cells,” said lead author Karen Marshall from the University of Sussex in Britain.

Further, stopping the protein aggregating in people with Alzheimer’s can slow down the progression symptoms of the disease, said the paper published in the journal Scientific Reports.

“We hope to work towards finding a strategy to do this (stop the protein) in the lab and reverse the damaging effects of toxic Amyloid-beta,” Marshall added.

In people with Alzheimer’s disease, Amyloid-beta sticks together to make amyloid fibrils which form plaques between neurons in the brain.

The build-up of these plaques causes brain cells to die, leading to the decline in mental skills of patients suffering from the disease.

Why this particular protein’s “stickiness” causes cells to die is not known yet, the researchers said.

“Understanding how the brain protein Amyloid-beta causes nerve cell death in Alzheimer’s patients is key if we are to find a cure for this disease,” Marshall said.

“This is a really exciting new tool that will contribute to research to uncover the causes for Alzheimer’s disease and enable tangible progress to be made towards finding targets for therapy,” noted Louise Serpell, Professor at the University of Sussex.

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Foodman Vishal Singh Honored for Hunger Free World Mission in Bangkok

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Lucknow: Vishal Singh, a renowned social worker from Lucknow, also known as Foodman, has once again made India proud. He was honored by the Happy Hands Gloves Cooperative Limited Company in Korathai, Thailand, for his work with the Hunger Free World Mission.

The Hunger Free World Mission’s meeting was held in Korathai, Thailand, under Vishal Singh’s leadership. Representatives from several countries, including Mr. Raja Dwivedi (Managing Director of Happy Hands Gloves Limited), Thailand Coordinator Mr. Raja Mishra, and member Mr. Varun Singh, attended the event.

Under Vishal Singh’s leadership, the attendees took a pledge to work together toward creating a hunger-free world.

Speaking on the occasion, Vishal Singh explained that the main goal of the Hunger Free World Mission is social participation. He said the mission is not just about feeding people but also about meeting other basic needs of those who are struggling. The mission focuses on helping families of terminally ill patients in hospitals by providing food and shelter. It also works to fulfill essential needs like education, jobs, and care for the elderly.

For the last 16 years, the Vijay Sri Foundation has been providing free services, benefiting thousands of people. Vishal Singh highlighted that the mission aims to gain global recognition like other organizations such as WHO, WWF, and Red Cross, which work for social causes.

During this meeting, Vishal Singh was appointed as the Chairman of the Hunger Free World Mission by representatives from various countries. They also discussed holding regular meetings in different countries to push the mission forward.

Business tycoon Dr. Abhishek Verma has also supported this humanitarian mission, vowing to promote the idea of “Seva Parmo Dharma” (Service is the highest duty) worldwide. Vishal Singh praised him, stating that people like Dr .Abhishek Verma inspire others to work for the betterment of society.

Recently, Romania’s Ambassador, Mr . Daniela Sezonov Ţane, invited Vishal Singh to the Romanian Embassy in Delhi, where they discussed the mission in detail. Impressed by his humanitarian work, she honored Vishal Singh and invited him to Romania to take the mission forward .

Food man Vishal Singh has been serving the people of India for the past 16 years. Through the Vijay Sri Foundation, he provides free meals to cancer patients & their families ,shelter, and education for women & children along with running free old-age homes in Lucknow.

In addition to his humanitarian work, Vishal Singh also addresses issues like crime and corruption through his role as Chairman of Seva Path Media and Managing Director of Vijay Sri Foundation.

During the COVID-19 pandemic, Vishal Singh and his team worked tirelessly to provide food and help to the needy, including starving children, elderly citizens, and pregnant women. Despite contracting the virus himself, he continued to assist others after his recovery. He even created a life-saving oxygen regulator using household items, which was praised by doctors both in India and abroad.

In his address at the meeting, Vishal Singh spoke about his mission to create a hunger-free world. He pointed out that India’s large population, along with issues like unemployment and poverty, has caused the country to fall on the Hunger Index. He urged people to contribute just one handful of grains daily to help create a hunger-free world.

He concluded by saying that through social participation, we can empower the people around us, meet their basic needs, and work together to build a stronger, more prosperous, and developed society.

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