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Scientists solve blood clot deaths in cancer patients

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8 years ago

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New Zealand, blood clots, chemotherapy, University of Otago, researchers, scientists, tumour in vital organs, Associate Professor Alex McLellan, blockage of major blood vessels, preventing oxygen

Cancer

Wellington: New Zealand scientists have unlocked the mystery of why so many cancer patients die of blood clots while undergoing chemotherapy in a study. Chemotherapy stimulates release of tiny bubbles from the surface of cancer cells, causing the potentially fatal clots, said the study by University of Otago researchers that came out on Wednesday, Xinhua news reported.

Most deaths from cancer were caused by uncontrolled growth of tumour in vital organs, but the second most common way that cancer kills is by triggering blood clotting resulting in thrombosis. The clots cause blockage of major blood vessels, preventing oxygen and nutrients to vital organs.

Despite being life-prolonging, chemotherapy is thus associated with a six-to-seven fold increase in the risk of thrombosis in cancer patients. The link between cancer and thrombosis was noted over 100 years ago, but the reasons for the association had been elusive, Associate Professor Alex McLellan said in a statement.

McLellan’s team discovered cancer cells treated with chemotherapy releasing lipid-rich bubbles from their membranes that activated coagulation (clotting) processes. “We now have insight into how these bubbles from dying cancer cells may cause thrombosis during chemotherapy,” McLellan said.

The research had showed that certain solid cancers were more active in promoting blood coagulation, as compared to lymphomas. “A general pattern is that cancers such as pancreatic, lung and brain cancers carry the largest risk of thrombotic events,” he said. The study opened the possibility of developing inhibitors to the major coagulation pathway identified in cancer cells.

 

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Corona

Covid toll in Karnataka is a worrying sign for state government

Published

2 years ago

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May 4, 2022

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Even though Karnataka recorded the lowest number of Covid deaths in April since the virus struck first in 2020, the state is recording a rise in the positivity rate (1.50 per cent). Five people died from the Covid infections in April as per the statistics released by the state health department. In March, the positivity rate stood around 0.53 per cent. In the first week of April it came down to 0.38 per cent, second week registered 0.56 per cent, third week it rose to 0.79 per cent and by end of April the Covid positivity rate touched 1.19 per cent.

on an average 500 persons used to succumb everyday in the peak of Covid infection, as per the data. Health experts said that the mutated Coronavirus is losing its fierce characteristics as vaccination, better treatment facilities and awareness among the people have contributed to the lesser number of Covid deaths.

During the 4th and 6th of April two deaths were reported in Bengaluru, one in Gadag district on April 8, two deaths were reported from Belagavi and Vijayapura on April 30. The first Covid case was reported in the state in March 2020 and three Covid deaths were recorded in the month. In the following month 21 people became victims to the deadly virus, and May 2020 recorded 22 deaths. The death toll recorded everyday after May crossed three digits. However, the third wave, which started in January 2

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