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Avocado seed extract shows anti-inflammatory activity

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Researchers have identified that an extract from avocado seeds exhibited anti-inflammatory properties in a laboratory study.

The team, including Joshua Lambert from Penn State, said that it represents a potential source for novel anti-inflammatory compounds that could be developed as a functional food ingredient or pharmaceuticals.
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The researchers developed the extract over the last decade as a food colourant and it is not known whether the compounds responsible for the extract’s vibrant orange colour play any role in its ability to inhibit the production of pro-inflammatory mediators, said Lambert.

To determine the anti-inflammatory properties of the avocado seed extract, the researchers used cell culture models and enzymes that are important in immune response and inflammatory diseases.

A class of immune cells called macrophages were grown in petri dishes and activated with a pro-inflammatory stimuli in the presence or absence of the avocado seed extract.

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The researchers measured the production of important pro-inflammatory mediators and signalling pathways in the cells after treatment with the extract.

“The next step, before we can draw further conclusions about the anti-inflammatory activity of this avocado seed extract, will be to design animal model studies,” Lambert explained.

“The level of activity that we see from the extract is very good. We saw inhibitory activity at concentrations in the low microgram-per-millilitre range, which is an acceptable amount of activity to justify further studies,” Lambert added.

The discovery could be important because cancer, cardiovascular diseases, arthritis, colitis and many more serious conditions are associated with chronic inflammation, suggests the study published in the journal Advances in Food Technology and Nutritional Sciences.

Corona

Covid toll in Karnataka is a worrying sign for state government

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Even though Karnataka recorded the lowest number of Covid deaths in April since the virus struck first in 2020, the state is recording a rise in the positivity rate (1.50 per cent). Five people died from the Covid infections in April as per the statistics released by the state health department. In March, the positivity rate stood around 0.53 per cent. In the first week of April it came down to 0.38 per cent, second week registered 0.56 per cent, third week it rose to 0.79 per cent and by end of April the Covid positivity rate touched 1.19 per cent.

on an average 500 persons used to succumb everyday in the peak of Covid infection, as per the data. Health experts said that the mutated Coronavirus is losing its fierce characteristics as vaccination, better treatment facilities and awareness among the people have contributed to the lesser number of Covid deaths.

During the 4th and 6th of April two deaths were reported in Bengaluru, one in Gadag district on April 8, two deaths were reported from Belagavi and Vijayapura on April 30. The first Covid case was reported in the state in March 2020 and three Covid deaths were recorded in the month. In the following month 21 people became victims to the deadly virus, and May 2020 recorded 22 deaths. The death toll recorded everyday after May crossed three digits. However, the third wave, which started in January 2

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