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Common antacid can treat TB: Study

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London: Scientists have identified an over-the-counter antacid that can help fight against the global pandemic tuberculosis that kills nearly 1.5 million people a year.

The team from the Swiss Federal Institute of Technology in Lausanne, Switzerland found the antacid called Lansoprazole to be effective against M. tuberculosis but only when the bacterium grows inside cells.

The researchers examined the underlying biology and found that Lansoprazole kills the bacterium after the human cells convert it into a sulphur-containing metabolite. It targets a particular enzyme that is crucial for the bacterium to produce energy, thereby killing it off.

“Being highly active against drug-resistant strains of M. tuberculosis, this novel class of drugs provides us with an excellent opportunity to treat tuberculosis,” said lead researcher Stewart Cole.

In addition, when the scientists tested Lansoprazole against a wide range of other bacteria, it proved to be highly selective for M. tuberculosis, said the study published in the journal Nature Communications.

The EPFL researchers used a method they had previously developed which can reflect what happens when the bacterium infects a lung much better than conventional screening assays used in tuberculosis research.

The scientists screened a large panel of already approved drugs, and identified the blockbuster antacid Lansoprazole, known commercially as Prevacid, as a potential anti-tuberculosis medication.

Lansoprazole belongs to a class of drugs known as “proton-pump inhibitors” that keep the stomach from pumping too much acid, thus preventing heartburn and ulcers.

Corona

Covid toll in Karnataka is a worrying sign for state government

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Even though Karnataka recorded the lowest number of Covid deaths in April since the virus struck first in 2020, the state is recording a rise in the positivity rate (1.50 per cent). Five people died from the Covid infections in April as per the statistics released by the state health department. In March, the positivity rate stood around 0.53 per cent. In the first week of April it came down to 0.38 per cent, second week registered 0.56 per cent, third week it rose to 0.79 per cent and by end of April the Covid positivity rate touched 1.19 per cent.

on an average 500 persons used to succumb everyday in the peak of Covid infection, as per the data. Health experts said that the mutated Coronavirus is losing its fierce characteristics as vaccination, better treatment facilities and awareness among the people have contributed to the lesser number of Covid deaths.

During the 4th and 6th of April two deaths were reported in Bengaluru, one in Gadag district on April 8, two deaths were reported from Belagavi and Vijayapura on April 30. The first Covid case was reported in the state in March 2020 and three Covid deaths were recorded in the month. In the following month 21 people became victims to the deadly virus, and May 2020 recorded 22 deaths. The death toll recorded everyday after May crossed three digits. However, the third wave, which started in January 2

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