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Molecule that helps gastric cancer patients survive longer

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Beijing: Researchers have discovered a molecule that can help clinicians predict survival time of people afflicted with gastric cancer, a significant health problem in developing countries which is typically associated with late-stage diagnosis and high mortality.

Patients whose primary gastric cancer lesions express high levels of microRNA 506 have significantly longer survival times compared to patients with low miR-506 expression, the findings showed.

In addition, miR-506 suppresses tumour growth, blood vessel formation, and metastasis or cancer spread, the study noted.

“Our study suggests that miR-506 acts as a tumour suppressor in gastric cancer,” explained lead investigator Xin Song from Southern Medical University in Guangzhou, China.

“Epithelial-to-mesenchymal transition (EMT) is an important process that enables cancer cells to invade their surroundings and to metastasise,” Song said.

“Our study presents evidence that miR-506 is a potent inhibitor of EMT,” Song noted.

The study involved 84 patients who had undergone cancer surgery.

When samples were divided into groups with miR-506 levels above and below the mean, survival was found to be significantly longer in patients with high miR-506 expression.

The investigators next examined miR-506 expression in cells from seven gastric cancer cell lines.

They found that gastric cancer cells had lower levels of miR-506 than normal stomach tissue.

The findings appeared in The American Journal of Pathology.

Corona

Covid toll in Karnataka is a worrying sign for state government

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Even though Karnataka recorded the lowest number of Covid deaths in April since the virus struck first in 2020, the state is recording a rise in the positivity rate (1.50 per cent). Five people died from the Covid infections in April as per the statistics released by the state health department. In March, the positivity rate stood around 0.53 per cent. In the first week of April it came down to 0.38 per cent, second week registered 0.56 per cent, third week it rose to 0.79 per cent and by end of April the Covid positivity rate touched 1.19 per cent.

on an average 500 persons used to succumb everyday in the peak of Covid infection, as per the data. Health experts said that the mutated Coronavirus is losing its fierce characteristics as vaccination, better treatment facilities and awareness among the people have contributed to the lesser number of Covid deaths.

During the 4th and 6th of April two deaths were reported in Bengaluru, one in Gadag district on April 8, two deaths were reported from Belagavi and Vijayapura on April 30. The first Covid case was reported in the state in March 2020 and three Covid deaths were recorded in the month. In the following month 21 people became victims to the deadly virus, and May 2020 recorded 22 deaths. The death toll recorded everyday after May crossed three digits. However, the third wave, which started in January 2

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