World
How do breast cancer cells spread?
New York : A team of researchers, including an Indian-origin scientist, has found that breast cancer cells spread to other parts of the body by sliding around other cells blocking their escape route out of the original tumour.
Metastasis — the spreading of cancer cells from one part of the body to another — is the leading cause of death among cancer patients.
The researchers demonstrated a quantitative ruler for measuring how well a cell is able to slide.
“By putting numbers to this cellular behaviour, we can not only discern which pathways regulate sliding, but also how much. This opens the door to finding the most powerful drivers of sliding behaviour and strategies to curb this invasive behaviour,” said one of the researchers, Anand Asthagiri of Boston’s Northeastern University.
To invade other tissues in the body, cancer cells migrate along protein fibers that serve as a path out of the original tumour.
The findings demonstrated the key role of cell sliding in supporting metastasis, and the molecular pathways that allow this to happen, the researchers stated.
The results provide a ruler to measure the extent to which genetic perturbations enable sliding, it offers a way to rank order molecular pathways and to identify combinations of genes that have synergistic effect on sliding potential.
“Sliding, and we believe invasiveness more broadly, is a property that’s progressively accrued, with each cancer-promoting event measurably shifting the degree of invasiveness. Having a ruler allows us to quantify how far cells have transformed and how effective one therapy is versus another,” Asthagiri noted.
For the study, published in Biophysical Journal, the team stamped a glass surface with micropatterned lines of fibronectin protein, and then used time-lapse microscopy to study collisions between pairs of cells deposited on the adhesive fibers.
On micropatterns, they mimicked conditions in the tumour environment, 99 percent of normal breast cells stopped and reversed direction upon physical contact with another cell.
By contrast, about half of metastatic breast cancer cells responded to collisions by sliding past the other cell, maintaining their migratory path along the protein track.
Lucknow: Vishal Singh, a renowned social worker from Lucknow, also known as Foodman, has once again made India proud. He was honored by the Happy Hands Gloves Cooperative Limited Company in Korathai, Thailand, for his work with the Hunger Free World Mission.
The Hunger Free World Mission’s meeting was held in Korathai, Thailand, under Vishal Singh’s leadership. Representatives from several countries, including Mr. Raja Dwivedi (Managing Director of Happy Hands Gloves Limited), Thailand Coordinator Mr. Raja Mishra, and member Mr. Varun Singh, attended the event.
Under Vishal Singh’s leadership, the attendees took a pledge to work together toward creating a hunger-free world.
Speaking on the occasion, Vishal Singh explained that the main goal of the Hunger Free World Mission is social participation. He said the mission is not just about feeding people but also about meeting other basic needs of those who are struggling. The mission focuses on helping families of terminally ill patients in hospitals by providing food and shelter. It also works to fulfill essential needs like education, jobs, and care for the elderly.
For the last 16 years, the Vijay Sri Foundation has been providing free services, benefiting thousands of people. Vishal Singh highlighted that the mission aims to gain global recognition like other organizations such as WHO, WWF, and Red Cross, which work for social causes.
During this meeting, Vishal Singh was appointed as the Chairman of the Hunger Free World Mission by representatives from various countries. They also discussed holding regular meetings in different countries to push the mission forward.
Business tycoon Dr. Abhishek Verma has also supported this humanitarian mission, vowing to promote the idea of “Seva Parmo Dharma” (Service is the highest duty) worldwide. Vishal Singh praised him, stating that people like Dr .Abhishek Verma inspire others to work for the betterment of society.
Recently, Romania’s Ambassador, Mr . Daniela Sezonov Ţane, invited Vishal Singh to the Romanian Embassy in Delhi, where they discussed the mission in detail. Impressed by his humanitarian work, she honored Vishal Singh and invited him to Romania to take the mission forward .
Food man Vishal Singh has been serving the people of India for the past 16 years. Through the Vijay Sri Foundation, he provides free meals to cancer patients & their families ,shelter, and education for women & children along with running free old-age homes in Lucknow.
In addition to his humanitarian work, Vishal Singh also addresses issues like crime and corruption through his role as Chairman of Seva Path Media and Managing Director of Vijay Sri Foundation.
During the COVID-19 pandemic, Vishal Singh and his team worked tirelessly to provide food and help to the needy, including starving children, elderly citizens, and pregnant women. Despite contracting the virus himself, he continued to assist others after his recovery. He even created a life-saving oxygen regulator using household items, which was praised by doctors both in India and abroad.
In his address at the meeting, Vishal Singh spoke about his mission to create a hunger-free world. He pointed out that India’s large population, along with issues like unemployment and poverty, has caused the country to fall on the Hunger Index. He urged people to contribute just one handful of grains daily to help create a hunger-free world.
He concluded by saying that through social participation, we can empower the people around us, meet their basic needs, and work together to build a stronger, more prosperous, and developed society.
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